Beilstein J. Org. Chem.2024,20, 815–822, doi:10.3762/bjoc.20.73
analogs. This discovery not only broadens the known chemical diversity of DMTs from bacteria, but also provides new insights into DMT biosynthesis in bacteria.
Keywords: bacterialterpenoid; cytochrome P450s; drimane-type sesquiterpenoid; Streptomyces clavuligerus; terpenoid biosynthesis; Introduction
Beilstein J. Org. Chem.2019,15, 2889–2906, doi:10.3762/bjoc.15.283
genome does not guarantee their partnership [87].
Studies of CYPs in bacterialterpenoid biosynthesis lags behind those of cyclases, and only a handful of examples are found in literature (Supporting Information File 1, Table S2). CYPs mostly catalyze prototypical hydroxylations, sometimes followed by
expression is the most widely used method to study complex terpenoid biosyntheses. Since many bacterialterpenoid BGCs are actinomycete-derived, terpene BGCs are often expressed in model Streptomyces hosts, such as Streptomyces albus, Streptomyces avermitilis, Streptomyces coelicolor, and Streptomyces
assist in refining our understanding of bacterialterpenoid biosynthesis.
Examples of bioactive terpenoids.
Repetitive electrophilic and nucleophilic functionalities in terpene and type II PKS-derived polyketide biosynthesis. a) Schematic representation. b) Type II PKS-derived polyketide biosynthesis. c